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KMID : 1123920090230020443
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 2 p.443 ~ p.451
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Study on the Anti-inflammatory Effects of Soyangin-Hyeongbangpaedok-san
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Heo Jeong-Won
Kang Hee
Ahn Kwang-Seok
Kim Sung-Hoon
Choi Seung-Hoon
Ahn Kyoo-Seok
Shim Bum-Sang
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Abstract
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Soyangin-Hyeongbangpaedok-san(SHBPDS) is used for treating upper respiratory infections, In an effort to investigate the anti-inflammatory effects of SHBPDS, we measured production of several cytokines and immunoglobulin in various immune cells. SHBPDS decreased the secretion of TNF-, but not that of IL-6 in PMA/A23187 stimulated HMC-1 cells. As for mouse B cells, it induced proliferation and caused differential effects in expressions of surface IgE as determined by flow cytometry and secretions of IgE, IgG1, ILA and INF-as measured by ELISA but showed little change in CD23 or CD69 expression. SHBPDS increased proliferation in anti-CD3/anti-CD28 stimulated CD4 Th cells. Under the Th1/Th2 polarization conditions, SHBPDS at 200 suppressed the secretion of INF- and IL-4. Based on the above results, we conclude that SHBPDS has antiinflammatory activities in mast cells and different immunomodulatroy effects in B cells and Th cells.
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KEYWORD
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Soyangin-Hyeongbangpaedok-san, anti-inflammatory effect, TNF-, IL-6, HMC, B cell, Th cell
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